PMOS Support Stack
These are the ingredients most often discussed in PMOS research — not a substitute for the hormonal and metabolic workup and treatment plan your clinician would build with you, but a reasonable starting point to bring to that conversation.
Myo-inositol (40:1 myo:D-chiro ratio)
We use: Ovasitol (Theralogix)2 level scoops/day, mixed into water (4,000 mg myo-inositol + 100 mg D-chiro-inositol total)The most-studied supplement for PMOS/PCOS — researched for improving insulin sensitivity, ovulation, and menstrual regularity. The 40:1 myo-to-D-chiro ratio matters: it mirrors the ratio naturally found in healthy ovarian tissue, and the published PCOS trials showing benefit used this specific ratio, not myo-inositol alone or a mismatched blend. We use Ovasitol specifically because it's the product most of those trials were actually built on, not a generic substitute at a lower dose — a half-dose version won't reproduce the studied effect. Can take 6–12 weeks of consistent use to show its full effect.
Vitamin D3
We use: Pure Encapsulations1,000–2,000 IU/day, more if a blood test shows you're deficientLow vitamin D is common in PMOS and linked to insulin resistance. Worth checking your level with a blood test rather than guessing the dose — take with a meal containing some fat, since it's fat-soluble.
Omega-3 (EPA/DHA)
We use: OmegaGenics 5-in-1 Fish Oil (Metagenics)1,000–2,000 mg combined EPA/DHA per day (2 softgels/day of a 1,000mg formula)Studied for its effect on inflammation and lipid levels, both often affected in PMOS. Take with food to reduce any fishy aftertaste or stomach upset.
N-acetylcysteine (NAC)
We use: Pure Encapsulations1,800 mg/day (3 x 600mg capsules)Researched for insulin sensitivity and ovulation, sometimes used alongside or as an alternative to metformin. The clinical trials showing benefit for PCOS/PMOS (Fulghesu et al., Thakur et al., among others) used 1,800 mg/day — a lower, token dose won't match what was actually studied. Occasional mild stomach upset is the most common side effect; taking it between meals with a small snack can help.
Shop this stack
Dr. Angel stocks practitioner-grade versions of these ingredients through Arte & Cera Supplemental Support, his Fullscript dispensary, which handles checkout, payment, and shipping directly — Arte & Cera never sees your payment details.
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Worth knowing
Myo-inositol and NAC are generally well tolerated, but talk to your provider before combining supplements with metformin or other PMOS medications.
These statements have not been evaluated by the Food and Drug Administration. Supplements are not intended to diagnose, treat, cure, or prevent any disease. This is educational information, not a personalized recommendation — talk to your provider before starting anything new, especially alongside medications or if you’re pregnant, breastfeeding, or managing a health condition.